LOVD v.3.0 - Leiden Open Variation Database
Online gene-centered collection and display of DNA variants
LOVD 3.0 News
|LOVD 3.0 build 29 released
||Ivo Fokkema, 2023-02-23|
|Today, LOVD 3.0 build 29 has been released.
New features implemented, amongst others:
Added an visual HGVS syntax checker tool.
This is an online form that takes a variant and finds out whether it seems to be described following the HGVS nomenclature.
The form accepts either a single variant input, or a batch variant input, where a list of variants can be pasted into the input form.
In both cases, it checks the variants' syntax and suggests a correction when possible.
It also allows to validate variants using the VariantValidator service.
When generating a suggested fix ourselves, we express our level of confidence that this correction is indeed as intended, in the text of the suggestion.
The interface allows downloading the results to a text file so that the user can store the result of the analysis.
You can find this tool in the scripts folder.
Bugs fixed, amongst others:
Fixed some URL parsing issues;
Several fixes in and improvements to the VariantValidator library;
Fixed issue with the LOVD2-style API not fully working;
Fixed the connection to Mutalyzer, since they changed their URL, breaking all interactions with their services;
Fixed several issues with running LOVD on PHP8.1;
Updated the links to dbSNP since they changed their URLs;
Added several fixes to the position fixing script.
Closes #526, #575 and #618.
See the changelog.
Download the new build.
LOVD scripts included: LOVD2 file converter 3.0-29, Reading Frame Checker 3.0-28, RefSeqParser 3.0-29, Variant position fixer 3.0-29, Variant Validation 3.0-29.
Manual version included: June 15th, 2021.
News older than 12 months can be found in the archive.
|Last modified 2023/02/23 12:16:52 CET
When using or discussing LOVD please refer to:
Fokkema IF, Kroon M, López Hernández JA, Asscheman D, Lugtenburg I, Hoogenboom J, den Dunnen JT.
The LOVD3 platform: efficient genome-wide sharing of genetic variants.
Eur J Hum Genet (2021).